This study will play a central role in outlining the pattern, situation and determinant factors associated with safe sexual experience among students in St.Mary's University College in particular and private and public Universities all over Ethiopia in general. This research will have a say on the general interventions/ programs and pave a way to design or redesign new interventions with new-fangled approach on HIV/AIDS and other STIs responses in private Universities in Ethiopia. The study tried to investigate and determine factors of safe sexual behaviors of St.Marry's University College students in the course of answering the research questions listed here below. 1. Among the following factors (gender, age, alcohol use, chat use, listening to rap music and watching rap videos, peer influence, and parental influence) which are the best factors to influence or associate with students to practice safe sexual behavior? 2. What determinants predict safe sexual activity among St.Marry's University college students?