High Quality Content by WIKIPEDIA articles! The Pre-Columbian era incorporates all period subdivisions in the history and prehistory of the Americas before the appearance of significant European influences on the American continents, spanning the time of the original settlement in the Upper Paleolithic to European colonization during the Early Modern period. While technically referring to the era before Christopher Columbus' voyages of 1492 to 1504, in practice the term usually includes the history of American indigenous cultures until they were conquered or significantly influenced by Europeans, even if this happened decades or even centuries after Columbus' initial landing.