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This issue of Anesthesiology Clinics focuses on Preoperative Patient Evaluation and is edited by Dr. Zdravka Zafirova and Dr. Richard Urman. Article topics include: Designing and Running a Preoperative Clinic; Preoperative Laboratory Testing; Patients with Cardiac Disease Undergoing Noncardiac Surgery; Preoperative Evaluation and Estimation of Pulmonary Risk; Stratification and Risk Reduction of Perioperative Acute Kidney Injury; Anticoagulants and Hematologic Disorders and Anemia; Nutrition and Prehabilitation; Perioperative Management of Diabetes and Other Endocrine Conditions; Preoperative Management of the Geriatric Patient, including Frailty and Cognitive Impairment Assessment; Management of Challenging Pharmacological Issues, including Chronic Pain and Substance Abuse Disorders; Assessment of the Pregnant Patient; Genomics Testing and Personalized Medicine in the Preoperative Setting; Shared Decision Making; Preoperative Management of Medications; Perioperative Surgical Home Models; and Preoperative Evaluation of the Pediatric Patient.