Die präparative Chromatographie ist ein Verfahren zur Reinigung auch kleiner Mengen von Produkten in kürzester Zeit. In diesem interdisziplinär angelegten Band erfahren Chemiker und Ingenieure, was sie im Alltag über naturwissenschaftliche und technologische Grundlagen dieser Methode wissen müssen und wie sie chromatographische Prozesse optimieren können. Dabei wird die Arbeit im Labormaßstab ebenso berücksichtigt wie die Konzeption industrieller Anlagen.-Derzeit gibt es am Markt kein anderes Buch mit ähnlichem Themenspektrum.
Die präparative Chromatographie ist ein Verfahren zur Reinigung auch kleiner Mengen von Produkten in kürzester Zeit. In diesem interdisziplinär angelegten Band erfahren Chemiker und Ingenieure, was sie im Alltag über naturwissenschaftliche und technologische Grundlagen dieser Methode wissen müssen und wie sie chromatographische Prozesse optimieren können. Dabei wird die Arbeit im Labormaßstab ebenso berücksichtigt wie die Konzeption industrieller Anlagen.-Derzeit gibt es am Markt kein anderes Buch mit ähnlichem Themenspektrum.
Professor Schmidt-Traub was Professor for Plant and Process Design at the Department of Biochemical and Chemical Engineering, University of Dortmund, Germany until his retirement in 2006. He is still active in the research community and his main areas of research focus on preparative chromatography, down stream processing, integrated processes, plant design and innovative energy transfer. Prior to his academic appointment, Prof. Schmidt-Traub gained 15 years of industrial experience in plant engineering.
Prof. Seidel-Morgenstern is the Director of the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany and holds the Chair in Chemical Process Engineering at the Otto-von-Guericke-Universität, Magdeburg, Germany. He received his Ph.D. in 1987 at the Institute of Physical Chemistry of the Academy of Sciences in Berlin. From there he went on to work as postdoctoral fellow at the University of Tennessee, Knoxville, USA. In 1994 he finished his habilitation at the Technical University in Berlin. His research is focused on New Reactor Concepts, Chromatographic Reactors, Membrane Reactors, Adsorption and Preparative Chromatography and Separation of Enantiomers amongst others.
Dr. Michael Schulte is Senior Director Emerging Businesses Energy at Merck KGaA Performance Materials, Darmstadt, Germany. In his Ph.D. thesis at the University of Münster, Germany he developed new chiral stationary phases for chromatographic enantioseparations. In 1995 he joined Merck and has since then been responsible for research and development in the area of preparative chromatography, including the development of new stationary phases, new separation processes and the implementation of Simulated Moving Bed-technology at Merck. In his current position one of his areas of research is the use of Ionic Liquids for separation processes.
Inhaltsangabe
Preface
INTRODUCTION On the Development of Chromatography Focus of the Book Recommendation to read this Book
FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Fluid Dynamics Mass Transfer Phenomena Equilibrium Thermodynamics Thermodynamic Effects on Mass Separation
STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS Column Packings Selection of Chromatographic Systems
CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION Introduction Engineering and Operational Challenges Chromatography Columns Market Chromatography Systems Market Process Control Packing Methods Process Troubleshooting Disposable Technology for Bio-Separations
PROCESS CONCEPTS Discontinuous Processes Continuous Processes Choice of Process Concepts
MODELING AND MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modeling HPLC plants Calculations Methods Parameter Determination Experimental Validation of Column Models
MODEL BASED DESIGN, OPTIMIZATION AND CONTROL Basic Principles and Definitions Batch Chromatography Recycling Chromatography Conventional Isocratic SMB Chromatography Isocratic SMB Chromatography under Variable Operating Parameters Gradient SMB Chromatography Multicolumn Systems for Bioseparations Chromatographic SMB Reactors Advanced Process Control
INTRODUCTION On the Development of Chromatography Focus of the Book Recommendation to read this Book
FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Fluid Dynamics Mass Transfer Phenomena Equilibrium Thermodynamics Thermodynamic Effects on Mass Separation
STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS Column Packings Selection of Chromatographic Systems
CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION Introduction Engineering and Operational Challenges Chromatography Columns Market Chromatography Systems Market Process Control Packing Methods Process Troubleshooting Disposable Technology for Bio-Separations
PROCESS CONCEPTS Discontinuous Processes Continuous Processes Choice of Process Concepts
MODELING AND MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modeling HPLC plants Calculations Methods Parameter Determination Experimental Validation of Column Models
MODEL BASED DESIGN, OPTIMIZATION AND CONTROL Basic Principles and Definitions Batch Chromatography Recycling Chromatography Conventional Isocratic SMB Chromatography Isocratic SMB Chromatography under Variable Operating Parameters Gradient SMB Chromatography Multicolumn Systems for Bioseparations Chromatographic SMB Reactors Advanced Process Control
APPENDIX B Data of Test Systems
Rezensionen
"Das Buch beginnt mit der Frage: Warum ein weiteres Buch zum Thema "Präparativer Chromatographie"... Für alle, die das Buch gelesen haben, wird sich diese Frage nicht mehr stellen. Es war absolut überfällig in einer Welt, in der wir langsam die Komplexität natürlicher Prozesse begreifen und die Überschreitung der Grenzen zwischen Chemie, Physik, den Ingenieurswissenschaften und weiteren Disziplinen zwingend notwendig wird." Nachrichten aus der Chemie
"...es gibt kein vergleichbares Werk. Für Pharmazeuten ist es besonders im Kontext der Herstellung, Reinigung und Isolierung von Wirkstoffen und Verunreinigungen außerordentlich nützlich." Pharmazie in unserer Zeit
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