Malaria and anemia are critical public health issues for pregnant women, particularly in endemic regions. This study assessed the prevalence of malaria and anemia among 130 pregnant women attending antenatal clinics at the General Hospital, Calabar in Africa. Using thick and thin blood smears and hematocrit methods, results indicated that only 3 women (2.31%) were infected with malaria (p=0.487), showing a low prevalence. The average packed cell volume (PCV) for malaria-infected women was 26.25±2.12, indicating anemia, while malaria-free women had a PCV of 33.75±3.11. The findings underscore the necessity for regular antenatal check-ups and monitoring of hematological parameters to ensure maternal health and appropriate interventions for anemia.