Prevalence of resistance against Methicillin, an antibiotic of the penicillin group of antibiotics, is a problem identified with infections of Staphylococcus aureus, which is a pathogenic bacterium that causes most of the skin infections. The current study was done to determine the extent of the MRSA prevalence in a selected community in Sri Lanka and to determine the effectiveness of the antibiotic Vancomycin against it. While more than a quarter of the studied population had Staphylococcus aureus in nasal surface, 5.7% of the isolates were found to be MRSA. The varying inhibitory concentrations of Vancomycin against the particular MRSA isolates were all 2µg/mL. None of the isolates recorded the MIC of Vancomycin against them above 4µg/mL, the concentration limit where any MIC above it is regarded as an indication of intermediate and resistance.