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Vitamin B12 is an essential element for proteins, phospholipids metabolism and neurotransmitters synthesis. It also plays a key role in DNA biosynthesis and cellular energy production. However, vitamin B12 deficiency leads to neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. Moreover, it's also associated with other diseases such as pernicious anemia and other hematologic manifestation.