Denture stomatitis, also called as Chronic Atrophic Candidiasis, is considered to be synonymous with the condition better known as denture sore mouth, a diffuse erythema and edema of the denture bearing area, often occurring with angular chelitis. It is the most common form of the oral disease .It is important to treat all patients with denture stomatitis, even if condition is mild and asymptomatic .Poor cleaning of the dentures may also lead to problems of denture stomatitis.Therefore can use denture cleansers.Microwave disinfection of dentures to prevent or treat denture stomatitis is recommended.Medical management of denture stomatitis mainly aims at removing the etiologic agent which is the candidal overgrowth. For the same we can suggest systemic antifungal agents.We can also manage denture related traumatic ulcers using ozone therapy that improves tissue healing and reduce pain and patient discomfort.Lasers and photodynamic therapy and cryosurgery are the surgical methods for management of denture stomatitis.