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It was a case-control study to evaluate the effect of obliteration of dead space by fixation of the mastectomy flaps by sutures to the underlying chest wall, on the amount and duration of post-operative fluid drainage and incidence of Seroma formation after breast surgery. For this, several techniques of flap fixation or wound drainage, as well as limitation of post-operative shoulder movement and the use of adhesive glue, have been investigated to improve primary healing and minimize Seroma formation. A re-operation may be necessary for cases of long standing persistent Seroma.