This document has been prepared for the defense of the Accreditation to Direct Research, in the theme of Occupational and Preventive Medicine. The last 15 years evidenced the efficacy of prevention in various conditions such as cardiovascular diseases, cancer, and well-being. Occupational medicine and preventive medicine are intimately linked. We spend one third of our life working. The work place seems best for promoting health on populations. Numerous factors increase morbidity such as sedentary and low physical activity, poor nutrition habits and stress at work. I demonstrated the cardio-metabolic benefits of exercise and diet in metabolic syndrome. I also demonstrated the interests of biomarkers of stress to follow the prolonged biological effects of a night shift in emergency physicians. I have built strong relations with exciting collaborators throughout the world on these themes. I have the ambition to promote French research in occupational medicine, and to extend its world-wide recognition. Currently, the digital world enables many opportunities for preventive health reachable. I am really grateful and honored to work with such eminent researchers sharing same convictions.