In the past the maxillofacial defects are difficult to treat and management. Maxillofacial prosthesis is one of the most important branch in prosthodontics. Now there are different treatment modalities and the management also advanced with applications of new materials. The patient with defect in maxillofacial region suffering from a major problem with his or her self and with the society but with the proper treatment of the defect and proper material selection the problem can be minimized. There are a missed ideas about this field specially for graduated and post-graduated dentist so, this book come to discuss in simple form the prosthetic management of Maxillofacial patients.