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Structural biology is the scientific study of the molecular structure of important macromolecules like amino acids, proteins and nucleic acids. It comes under the domain of molecular biology, but builds on the technological tools of biophysics like spectrometry, crystallography, proteolysis, scattering, etc. It also uses the principles of biochemistry to study, design, alteration and evolution of macromolecules. This book discusses the modern approaches of structural biology. It also elucidates the principles and applications of structural biology in a multidisciplinary manner. Experts and students in biotechnology, biophysics, biochemistry, structural biology and bioinformatics will be assisted by this book.