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Explains the principles, concepts, and definitions used by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) when assessing toxicological data on pesticide residues in food and establishing acceptable daily intakes. Intended to guide the design and interpretation of relevant toxicological studies, the book alerts readers to the multiplicity of factors, from the endocrinology of the animal species to the pharmacokinetic and pharmacodynamic properties of the pesticide, that can influence the validity of a study and determine its relevance to safety assessment.