Local anaesthesia and tooth extraction are one of the most important aspects of dentistry. It covers patient assessment and his/her suitability for local anaesthesia and surgery, pain control, neuroanatomy, neurophysiology, the pharmacokinetics of the drugs used in local anaesthesia and any local or systematic complications which may occur. Moreover, it covers indications and contraindications for tooth extraction, post-operative instructions and follow-up. Lastly, complications which may occur during or after tooth extraction and surgery, how to reduce and manage.