Prions and Diseases

Volume 1, Physiology and Pathophysiology
Herausgegeben:Zou, Wen-Quan; Gambetti, Pierluigi

• Broschiertes Buch

Produktbeschreibung

Volume I highlights the association of the cellular prion protein (PrP C ) with copper and zinc, the potential roles of PrP C in Alzheimer's disease and cancers, insoluble PrP C , PMCA, molecular and cellular mechanisms of PrP Sc formation and clearance, possible co-factors involved in the conversion of PrP C into PrP Sc , infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4899-9142-3
• 2013
• Seitenzahl: 252
• Erscheinungstermin: 13. Dezember 2014
• Englisch
• Abmessung: 235mm x 155mm x 14mm
• Gewicht: 388g
• ISBN-13: 9781489991423
• ISBN-10: 1489991425
• Artikelnr.: 41905917

Inhaltsangabe

Transmissible Spongiform Encephalopathy: from the High Middle Ages to Daniel Carlton Gajdusek.- The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein.- Role of Cellular Prion Protein in the Amyloid-ß Oligomer Pathophysiology of Alzheimer's Disease.- Cellular Prion Protein and Cancers.- Insoluble Cellular Prion Protein.- Protein Misfolding Cyclic Amplification.- Cofactor Involvement in Prion Propagation.- Prion Protein Conversion and Lipids.- New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating.- Infectious and Pathogenic Forms of Prion Protein.- Cellular Mechanisms of Propagation and Clearance.- Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains.- Modeling the Cell Biology of Prions.- Prion Strain Interference.- Introduction to Yeast and Fungal Prions.- Yeast Prions are Pathogenic, in-register Parallel Amyloids.