Probing Inclusion Complexes of Cyclodextrins with Amino Acids - Roy, Aditi; Saha, Subhadeep; Roy, Mahendra Nath
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Formations of host-guest inclusion complexes of two natural amino acids, namely, L-Leucine and L-Isoleucine as guests with ¿ and ¿-cyclodextrins as hosts have been investigated which include diverse applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing etc. Surface tension and conductivity studies establish the formation of inclusion complexes with 1:1 stoichiometry. The interactions of cyclodextrins with amino acids have been supported by density, viscosity, refractive index, hydration and solvation number measurements indicating higher…mehr

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Produktbeschreibung
Formations of host-guest inclusion complexes of two natural amino acids, namely, L-Leucine and L-Isoleucine as guests with ¿ and ¿-cyclodextrins as hosts have been investigated which include diverse applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing etc. Surface tension and conductivity studies establish the formation of inclusion complexes with 1:1 stoichiometry. The interactions of cyclodextrins with amino acids have been supported by density, viscosity, refractive index, hydration and solvation number measurements indicating higher degree of inclusion in case of ¿-cyclodextrin. L-Leucine interacts more with the hydrophobic cavity of cyclodextrin than its isomer. With the help of stability constant by NMR titration, hydrophobic effect, H-bonds and structural effects the formations of inclusion complexes have been explained.
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Autorenporträt
Miss Aditi Roy and Mr. Subhadeep Saha have been working as Ph. D. research fellows under the supervision of Prof. M. N. Roy in Department of Chemistry, University of North Bengal, India.Dr. M.N.Roy is a senior Professor who produced 27 PhDs, authored over 200 research articles and books in Chemistry and received UGC, Ameta and Bronze Medal awards.