The concept of probiosis, prebiosis and synbiosis have been recently emerged and being implemented in pharmaceutics to develop, designing and delivery of probiotic drugs which can be administered orally as other medicines with its efficient efficacy and least jeopardy. However, with the undergoing trends of its designing and discovery, the emphasis has been focused on to its bimolecular mode of action. The present review work would also emphasize the pros and cons of the probiotic food supplements with the necessity for the invent of preceding probiotic drugs which would rapidly pounce, quell and substitute the use of probiotic foods. The idea of this probiotic drug designing will be salutary to the society and would also meet with the cost.