Product related factors influencing the immunogenicity of interferon B - Haji Abdolvahab, Mohadeseh
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Therapeutic interferon beta is the first line treatment of relapsing remitting Multiple Sclerosis. However, despite their success in improving patient wellbeing, all IFN¿ products encounter a significant problem: immunogenicity. In some patients, IFN¿ products induce the formation of antidrug antibodies that undermine treatment efficacy and may even lead to treatment failure. These patients not only have a substantial health risk due to failing treatment, but are being treated with expensive products that no longer work. Developing low or non-immunogenic therapeutic IFN¿ products requires an…mehr

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Produktbeschreibung
Therapeutic interferon beta is the first line treatment of relapsing remitting Multiple Sclerosis. However, despite their success in improving patient wellbeing, all IFN¿ products encounter a significant problem: immunogenicity. In some patients, IFN¿ products induce the formation of antidrug antibodies that undermine treatment efficacy and may even lead to treatment failure. These patients not only have a substantial health risk due to failing treatment, but are being treated with expensive products that no longer work. Developing low or non-immunogenic therapeutic IFN¿ products requires an understanding of why these products are immunogenic. Preliminary data suggest several product related factors such as formulation, aggregation and epitopes influencing the immunogenicity of IFN¿-1b. Research described in this book aims to determine which of these potential triggers is causing immunogenicity. Our findings have pushed us one step closer to answering this question.
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Autorenporträt
Mohadeseh Haji Abdolvahab was born on 4th of February 1983 in Tehran, Iran. In April 2012, she joined the department of pharmaceuticals at Utrecht University,The Netherlands. Her PhD research was supervised by Prof. dr. H. Schellekens. During her PhD she studied multiple problems connected with immunogenicity of therapeutic interferon beta.