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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Progressive multifocal leukoencephalopathy (PML), also known as progressive multifocal leukoencephalitis, is a rare and usually fatal viral disease that is characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It occurs almost exclusively in people with severe immune deficiency, e.g. transplant patients on immunosuppressive medications, patients receiving certain kinds of chemotherapy, patients receiving Natalizumab (Tysabri) for multiple sclerosis, psoriasis patients on long-term Efalizumab (Raptiva) or AIDS patients.