This book highlights the side effects of FDA-approved antiviral drugs and the importance of plant-derived antiviral medicines as an alternative and more reliable source. Further, we detailed the development of diverse herbal medicines, intending to provide insights into the need for more exploration of natural sources as antiviral therapeutics. This book will provide a reasonable basis for the post-graduate students, researchers, scientists and interested industrialists aiming for drugs against various viral infections, including SARS-CoV-2. We believe that the comprehensive information about synthetic and plant-based drugs provided in this book enlightens the importance and focus on plant-based antiviral drugs, which will pave the way to use plant based phytochemicals as an alternate to synthetic antivirals.