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Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death…mehr

Produktbeschreibung
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death - from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. This book reflects the efforts of many in this exciting field of research where team and network formationsare essential to move ahead.
Autorenporträt
Dr.S. Vijayalakshmi nasceu na Índia (1986) e é autor de mais de 60 publicações científicas na área da Bioenergia, Biotecnologia, Engenharia Bioquímica. Tem vários projectos de investigação financiados pela DBT, ICMR, etc. Tem colaborações com Universidades na Alemanha, Arábia Saudita, Nigéria, E.U.A. e Taiwan. É beneficiária da Kothari Fellowship pela UGC.