Protein Kinase Inhibitors

From Discovery to Therapeutics
Herausgeber: Hassan, Md. Imtaiyaz; Noor, Saba

• Broschiertes Buch

Produktbeschreibung

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.

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Produktdetails

• Verlag: Elsevier Science & Technology
• Seitenzahl: 830
• Erscheinungstermin: 20. Mai 2022
• Englisch
• Abmessung: 192mm x 239mm x 50mm
• Gewicht: 1698g
• ISBN-13: 9780323912877
• ISBN-10: 0323912877
• Artikelnr.: 62757479

Inhaltsangabe

1. Kinase Inhibitors: An Overview 2. Protein Kinase Inhibitors and cancer
targeted therapy 3. Drug discovery for cancer therapy with special
reference to inhibitors of protein kinase pathway 4. An insight on
PI3K/Akt/mTOR inhibitors in cancer: opportunity and translational
perspectives 5. Recent advances in the therapeutic development of ERK
inhibitors 6. Emerging small-molecule inhibitors of ATM kinase targeting
cancer therapy 7. Targeting Pyruvate Kinase M2 Signaling for Development of
Effective Cancer Therapy 8. Serum and glucocorticoid-regulated kinase 1: A
potential target for anticancer therapy 9. AKT inhibitors in cancer therapy
10. Aurora kinase: An emerging potential target in therapeutics 11. The
Retroactive and Future Potentials of Aurora Kinases in the Treatment of
Cancer 12. Targeting the altered tyrosine kinases in colorectal cancer:
from inhibitors to drugs 13. PTEN-induced kinase1 (PINK1): Structure,
Functions and Role in Human Disease 14. Rho associated protein kinase 1 and
2 (ROCK1&ROCK2) as a potential emerging therapeutic drug target in
Alzheimer's disease 15. PDK inhibitors as therapeutic agents: An Overview
16. Polo-like kinases (PLKs): an antimitotic target 17. Src Kinase: An
Attractive Therapeutic Target for Prostate Cancer 18. Kinase inhibition in
Alzheimer's disease 19. Therapeutic Targeting of Glycogen Synthase
Kinase-3: Strategy to address neurodegenerative diseases 20. Microtubule
Affinity Regulating Kinase 4: a potential drug target from cancers to
neurodegenerative diseases 21. Receptor tyrosine kinase-like orphan
receptors ROR1/2: Insights into the mechanism of action, inhibition, and
therapeutic potentialIndrakant 22. Therapeutic Potential of Leucine Rich
Repeat Kinase 2 (LRRK2) Inhibitors for Parkinson's Disease Treatment 23.
Calcium calmodulin dependent protein kinase as potential drug target 24.
Therapeutics of Platelet derived growth factor (PDGF) and signaling in
different organs 25. EGFRC797S mutation and fourth generation EGFR tyrosine
kinase inhibitors (EGFR-TKIs) 26. Bacterial Histidine Kinases as potential
Antibacterial Drug Targets 27. Bacterial Protein Kinases: a target to
inhibit the bacterial infections 28. Nanotechnology-based targeted delivery
systems for Protein Kinase inhibitors in Cancer therapy