Protein Misfolding in Neurodegenerative Diseases

Mechanisms and Therapeutic Strategies
Herausgeber: Sewell, Robert D E

• Gebundenes Buch

Produktbeschreibung

Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.

Produktdetails

• Verlag: Taylor and Francis
• Seitenzahl: 596
• Erscheinungstermin: 1. Dezember 2007
• Englisch
• Abmessung: 234mm x 156mm x 32mm
• Gewicht: 1002g
• ISBN-13: 9780849373107
• ISBN-10: 0849373107
• Artikelnr.: 23596306

Autorenporträt

H. John Smith, Claire Simons, Robert D. E. Sewell

Inhaltsangabe

INTRODUCTION. Protein Folding. ALZHEIMER'S DISEASE. Alzheimer's Disease:
Epidemiology, symptoms and clinical pathology. Improving Cholinergic
Transmission. Reduction in Plaque Formation. Carbonic Anhydrase Activation.
Reduction of Intracellular Neurofibrillary Tangles from Tau Protein.
Oxidative Stress Reduction. Enhancement of Brain Retinoic Acid Levels.
Sulfatase Inhibitors and Cognitive Enchancement. PARKINSON'S DISEASE.
Epidemiology, Symptoms and Clinical Pathology. Restoring Dopamine Levels.
Anticholinergics. RARER NEURODEGENERATIVE DISEASES. Huntington's Disease.
Amyotrophic Lateral Sclerosis (Motor Neurone Disease). Transmissible
Spongiform Encephalopathies (TSEs) - Bovine Spongiform Encephalopathy (BSE)
- Creutzfeldt-Jacob Disease (CJD, vCJD) - Scrapie. Overview - Common Role
of Protein Misfolding in Neurodegenerative Diseases.