Neha Gogia, Sandeep Kumar Singh, Vidyadhara Devarunda Jaganath

Protein Misfolding in Neurodegenerative Diseases

• Broschiertes Buch

Produktbeschreibung

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

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Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 300
• Erscheinungstermin: 1. März 2025
• Englisch
• Abmessung: 229mm x 151mm
• ISBN-13: 9780443187162
• ISBN-10: 0443187169
• Artikelnr.: 68540947

Autorenporträt

Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University's International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases.

Inhaltsangabe

1. Maintenance of balanced proteome homeostasis 2. Determinants of protein
misfolding, aggregation in neuronal cell death 3. Classification,
structure, and function of protein aggregates in proteinopathies 4. Protein
aggregation and cellular and molecular mechanisms in neurodegenerative
disease 5. Advances in methods to detect and study protein aggregation 6.
Organelle specific protein quality control 7. Molecular chaperones and
co-chaperones in proteostasis 8. The ubiquitin-Proteasome System (UPS) and
Autophagy lysosomal proteolytic pathways 9. Alterations in protein quality
control 10. Alternate mechanisms to maintain proteome homeostasis 11.
Advances in developing novel therapeutics, strategies, approaches and use
of emerging techniques 12. Challenges in translating laboratory findings to
drug development 13. Advancements in drug delivery technologies for protein
misfolding diseases