Protein-Protein Interaction Regulators

Herausgeber: Roy, Siddhartha; Fu, Haian

• Gebundenes Buch

Produktbeschreibung

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein-Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

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Produktdetails

• Verlag: RSC Publishing
• Seitenzahl: 398
• Erscheinungstermin: 15. Dezember 2020
• Englisch
• Abmessung: 236mm x 157mm x 25mm
• Gewicht: 771g
• ISBN-13: 9781788011877
• ISBN-10: 1788011872
• Artikelnr.: 58774191

Inhaltsangabe

Introduction; Protein
protein interaction interfaces and their functional implications; Protein
Protein interaction networks in human disease; High Throughput Screening Methods for PPI inhibitor discovery; Computational structural modeling to discover PPI modulators; Small molecule inhibitors of E3 ubiquitin ligases; Hydrogen bond surrogate stabilized helices as Protein
Protein interaction inhibitors; Helix
mimetics as Protein
Protein Interaction Inhibitors; Discovery and Development of Mcl
1 Inhibitors as Anti
cancer Therapeutics: Hit to Clinical Candidate Optimization; Pharmacological Regulation and Functional Significance of Chromatin Binding by BET Tandem Bromodomains; Small
molecule modulators of Protein
Protein Interactions: focus on 14
3
3 PPIs; Discovery of AMG 232, a small molecule MDM2 inhibitor in clinical development and its back
up clinical candidate, AM
7209; Small Molecule Inhibitors of Myc
Max Interaction and DNA Binding; Small Molecule Modulators of Endo
Lysosomal Toll
Like Receptors