The development of scientific and technological progress in aviation is accompanied by a systematic increase in the share of psycho-emotional overload of the air traffic controllers. In accordance with the Regulation on System-Hierarchical Principles of Formation and Interaction of Parameters, "Human Factor" with Components of Air Navigation System, developed on the basis of P.K. Anokhin's theory of functional systems, it was revealed that under these conditions, on the one hand, there are increasing shifts of psychophysiological cognitive, audio and dispersion ECG indicators, on the other hand, personnel erroneous actions, accompanied by decreasing "safety of flights", become more frequent. Against this background, control-corrective measures and trainings using automated systems normalize disturbed psychophysiological indices, accompanied by a decrease in erroneous actions of personnel. The book is intended for specialists and scientists in different fields of "human factor" research in air navigation, aviation psychology, biology and medicine.