The text is meant to provide valuable information on the psychosocial determinants of adherence to antiretroviral medication among people living with HIV/AIDS. The text aims at providing assistance to all stakeholders including the women living with HIV/AIDS, health practitioners, family members, the government and Non governmental organizations. The study on psychosocial determinants was borne out of experience with clients who are living with HIV/AIDS, and have psychological issues concerning the perception of the society on the use of antiretroviral regimens. The clients were found to have challenges with adherence to antiretroviral regimens, most of whom are suffering from conditions that require counselling due to the stigma associated with the way the society perceives people taking the antiretroviral medication.