The purpose of this study is to assess the public relation practices in Ministry of Women, Children and Youth Affairs Office of the Federal Democratic Republic of Ethiopia. Moreover the study sought to assess how the activities of public relations are practiced, the significance of public relation in contributing to the ministry's overall objectives and to identify the factors inhibiting and challenges of public relation practices. The study adopted mixed method research approach. Open and closed ended questionnaires, unstructured in-depth interview and focus group discussions were data collection tools used to conduct the study. By conducting purposeful sampling 150 questionnaires, unstructured in-depth interview of six respondents and one focus group discussions were conducted and reflected their opinion. Frequency and percentage statistical techniques were used for quantitative data analysis by using SPSS statistical software.