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High Quality Content by WIKIPEDIA articles! Publication bias arises from the tendency for researchers, editors, and pharmaceutical companies to handle the reporting of experimental results that are positive (i.e. they show a significant finding) differently from results that are negative (i.e. supported the null hypothesis) or inconclusive. In an effort to decrease this problem some prominent medical journals require registration of a trial before it commences so that unfavorable results are not withheld from publication.