Revitalization procedures have helped to develop regenerative endodontics in the clinical scenario. In place of blood clot, various natural and synthetic scaffolds are being tried like platelet- rich plasma, platelet-rich fibrin, or even the recently developed Nanofibrous and bioactive scaffolds. All this implies a highly evolving field. The introduction and implementation of these findings into clinical practice will definitely bring forth a positive influence on patient- centered outcomes in terms of disease resolution and rate of tooth survival.The innovations in technology, the discovery of newer materials and medicaments, and a better understanding of the principles of tissue engineering has all brought about a paradigm shift in the treatment of non-vitalized teeth. Moreover, recent case reports from multiple investigators support the feasibility of developing biologically based revitalization in endodontic procedures designed to restore a functional pulp-dentin complex. In short, the question is no longer whether the revitalization procedures can be successful instead,it is the issues that must be addressed to develop a safe, effective, and consistent method for regeneration.