Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of the drug administration on resultant pharmacodynamic and pharmacokinetics parameters. The significance of these day-night variations has not been over looked from the drug delivery perspective and pharmaceutical scientists have displayed considerable ingenuity in development of time delayed drug delivery systems to address emerging Chronotherapeutic formulations. Pulsincap technique helps us to deliver the drug at colon which helps to treat chronotherapeutics.