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Pyrrole and pyrrolopyrimidine derivatives are important and versatile compounds. The main objective of the present book is to provide an overview in the synthesis and reactions of pyrrole and pyrrolopyrimidine derivatives and their used in medicine and study their Pharmacological activities such as "Anti-inflammatory, Analgesic, Antimicrobial, Anti-hepatoprotective, Anti-hyperglycemic, Anti-cancer and Anti-viral activities".