QSAR studies on Topoisomerase-II inhibitors - Sharma, Meenakshi;Ratan, Yashumati;Kishore, Dharm
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The objective of drug discovery phase is to synthesize lead compounds, new analogs with improved potency, reduced off target activities, and physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics. This optimization is accomplished through empirical modification of the hit structure and/or by employing structure-based design if structural information about the target is available. The goal of present work is to design drug with minimum side effect and maximum potency. 2D QSAR is planned using Multiple Linear Regression Analysis, for achieving the goal, which can…mehr

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Produktbeschreibung
The objective of drug discovery phase is to synthesize lead compounds, new analogs with improved potency, reduced off target activities, and physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics. This optimization is accomplished through empirical modification of the hit structure and/or by employing structure-based design if structural information about the target is available. The goal of present work is to design drug with minimum side effect and maximum potency. 2D QSAR is planned using Multiple Linear Regression Analysis, for achieving the goal, which can help in recognizing the important descriptor that can help in increasing the potency of anticancer drugs.
Autorenporträt
Meenakshi Sharma: M.Sc. Pharmaceutical Chemistry from Banasthali University and is a researcher currently in Dept of Chemistry, Banasthali University,Rajasthan. Her area of interests are Synthetic Medicinal Chemistry and Drug Design.