Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Herausgegeben:Neidle, Stephen

• Gebundenes Buch

Produktbeschreibung

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

Produktdetails

• Annual Reports in Medicinal Chemistry Volume 54
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S0065-7743(20)X0002-9
• Englisch
• Abmessung: 29mm x 152mm x 229mm
• Gewicht: 1040g
• ISBN-13: 9780128210178
• Artikelnr.: 67578869

Autorenporträt

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Inhaltsangabe

Part 1. Fundamentals of quadruplexes and their biology

1. Fundamentals of G-quadruplex biology


F. Brad Johnson




2. Quadruplex structure and diversity


Fernaldo Richtia Winnerdy and Anh Tuân Phan



Part 2. Quadruplex targets in human and other organisms


3. Telomeric quadruplexes as therapeutic targets


Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama




4. Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy


Emanuela Ruggiero and Sara N. Richter




5. Quadruplex detection in human cells


David Monchaud



Part 3. Discovery and design of quadruplex-binding compounds


6. An overview of quadruplex ligands: Their common features and chemotype diversity


Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria




7. Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding


Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider




8. Quadruplex-interacting compounds for regulating the translation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers


Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou




9. Click and combinatorial approaches to quadruplex ligand discovery


Jyotirmayee Dash, Puja Saha and Khushnood Fatma




10. Quadruplex nucleic acids in KRAS targeted-cancer therapy


Luigi E. Xodo




11. Transcriptional regulation of MYC through G-quadruplex structures


Sumirtha Balaratnam and John S. Schneekloth


12. KIT promoter: Structure, function and targeting


Silvia Ceschi and Claudia Sissi




13. Quadruplex targets in neurodegenerative diseases


Janez Plavec




14. Metal complexes as G-quadruplex binders


Tim Kench and Ramon Vilar




15. Challenges in developing small-molecule quadruplex therapeutics

Stephen Neidle