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Sickle cell disease is an inherited blood disorder characterized by a chronic hemolytic anemia that contributes to painful crises. It is an autosomal recessive disorder caused by production of abnormal hemoglobin S and is associated with high morbidity and mortality. It may influence the quality of life of children, who may require more frequent hospital care. Quality of life refers to people's ability to function in the ordinary tasks of living. It moves beyond direct manifestations of illness to the patient's personal morbidity.