Trevor Byrne

Quantifying Protein Adsorption on Combinatorial Metal Films

A High Throughput Approach Using Novel Ex-situ and In-situ Techniques With Electron Microprobe and Spectroscopic Ellipsometry

• Broschiertes Buch

Produktbeschreibung

This book is a 2008 MSc thesis that presents new
high throughput techniques for quantifying protein
adsorption on metal surfaces. Using a materials
synthesis approach developed at Dalhousie
University, combinatorially sputtered Al-, Nb-, Ta-,
and Ti-containing films were prepared and
characterized. In order to test the metal surfaces
for their protein affinity ex-situ, a calibration
method was devised for wavelength-dispersive
spectroscopy. Fibrinogen and albumin absorption
amounts on each film were correlated to their
compositional gradient and were directly compared to
the adsorbed amounts obtained ex-situ using
spectroscopic ellipsometry. A simple and novel flow
cell design is also presented here for use with
variable angle spectroscopic ellipsometry to study
the adsorption of liquid-borne species in-situ. The
flow cell allows a sample to be probed point by
point and at any common ellipsometric angle of
incidence, unlike other designs.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 92
• Deutsch
• Abmessung: 220mm
• ISBN-13: 9783639172010
• ISBN-10: 3639172019
• Artikelnr.: 26564605

Autorenporträt

Trevor Byrne obtained a BSc in Astrophysics at Saint Mary''s
University and completed his MSc under the guidance of Jeff Dahn
at Dalhousie University in Halifax, Nova Scotia. He is
currently researching Li-ion battery materials at Dalhousie.