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New trends of information technology based learning in new era is significant to overcome time and location constraints. Technologies were recommended to go instead of traditional learning conditions due to simplicity and positive influences for learning. By the evolution of computer and after that world wide web the trend changed into online or web based platform for learning. due to dynamism and flexibility optimality of user-tutor interaction is a strategic target. This book provides various types of optimization in e-learning systems to obtain the strategic objectives for users.