High Quality Content by WIKIPEDIA articles! Quechua is a Native American language family spoken primarily in the Andes of South America, derived from an original common ancestor language, Proto-Quechua. It is the most widely spoken language family of the indigenous peoples of the Americas, with a total of probably some 6 to 8 million speakers (estimates vary widely). Some speakers of Quechua also call it 'runa simi' (or regional variants thereof), literally 'people speech', although 'runa' here has the more specific sense of indigenous Andean people.