The quinolones continue to make a significant contribution in the fight against community or hospital acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of the quinolones. Summary of contents: 1. History and Introduction 2. The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System 3. Chemistry in the Periphery of the Quinolones 4. Mode of Action 5. The In Vitro Antibacterial Activity of Quinolones: A Review 6. Pharmacokinetics of Fluoroquinolones in Experimental Animals 7. Pharmacodynamics of Fluoroquinolones in Experimental Animals 8. Interaction of Quinolones with Host-Parasite-Relationships 9. Mechanisms of Resistance to Fluoroquinolones 10. Toxicology and Safety Pharmacology of Quinolones 11. Clinical Pharmacology 12. Concentration-Effect Relationship of the Fluoroquinolones 13. Clinical Use of Quinolones 14. Future Aspects
