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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Radiation-induced erythema multiforme may occur when phenytoin is given prophylactically to neurosurgical patients who are receiving whole-brain therapy and systemic steroids. There are many conditions of or affecting the human integumentary system the organ system that covers the entire surface of the body and is composed of skin, hair, nails, and related muscle and glands. In 1572, Geronimo Mercuriali of Forlì, Italy, completed De morbis cutaneis (translated "On the diseases of the skin"). It is considered the first scientific work dedicated to dermatology. In World War I, over two million days of service are estimated to have been lost by reason of skin diseases alone.