Provides a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly flash cards; question and answer format with over 700 questions.
Provides a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly flash cards; question and answer format with over 700 questions.
Jennifer Yu, MD, PhD, Associate Staff Physician, Departments of Radiation Oncology and Stem Cell Biology and Regenerative Medicine, Taussig Cancer Institute and Lerner Research Institute, Cleveland Clinic, Cleveland OH
Inhaltsangabe
CONTENTS Contributors Preface 1. Interaction of Radiation With Matter John F. Greskovich, Jr., Mihir Naik, and Marc Apple 2. Cell Survival Curves and Cell Death Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 4. Radiosensitivity and the Dose-Rate Effect Brian D. Yard and Mohamed E. Abazeed 5. Radiation Damage Repair and Models for Normal Tissues Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu 6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis Xingjiang Yu, Jennifer S. Yu, and Eli Bar 7. Linear Energy Transfer and Relative Biological Effectiveness Yvonne Pham and Chirag Shah 8. Assays for Cell, Tissue, and Solid Tumors C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa 9. Molecular Techniques, Assay Systems, and Signaling in Radiobiology Kailin Yang and Jennifer S. Yu 10. Biology of Cancer Kailin Yang and Jennifer S. Yu 11. Model Tumor Systems and Predictive Assays C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala 12. Cell Kinetics Matthew C. Ward and Richard Blake Ross 13. Factors Influencing Tumor Control and Complications Daesung Lee 14. Impact of Time, Dose, and Fractionation in Radiation Oncology Daesung Lee 15. Effects of Total Body Irradiation Sudha Amarnath 16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs Aditya Juloori and Michael A. Weller 17. Radiation Carcinogenesis Bindu V. Manyam and Michael A. Weller 18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni 19. Effects of Radiation on the Embryo and Fetus Yvonne Pham and Steven Oh 20. Doses and Risks in Nonradiation Oncology Subspecialties Frank Dong, Kevin Wunderle, and Salim Balik 21. Radiation Protection Taoran Cui and Peng Qi 22. Alternative Radiation Therapy Modalities Susan Kost and Andrew Godley 23. Brachytherapy and Stereotactic Radiosurgery Sudha Amarnath 24. Gene Therapy HyeonJoo Cheon 25. Chemotherapy and Targeted Agents Nikhil Joshi and Neil Woody 26. Hyperthermia Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu 27. Stem Cells Haidong Huang and Jennifer S. Yu 28. Immunotherapy Nikhil Joshi and Neil Woody 29. Radiogenomics Mohamed E. Abazeed Index
CONTENTS Contributors Preface 1. Interaction of Radiation With Matter John F. Greskovich, Jr., Mihir Naik, and Marc Apple 2. Cell Survival Curves and Cell Death Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 3. DNA, Chromosome and Chromatid Damage, Repair, and Measurement Ehsan H. Balagamwala, C. Marc Leyrer, Jeffrey A. Kittel, and Alex Almasan 4. Radiosensitivity and the Dose-Rate Effect Brian D. Yard and Mohamed E. Abazeed 5. Radiation Damage Repair and Models for Normal Tissues Aditya Juloori, Choamei Xiang, Michael A. Weller, and Jennifer S. Yu 6. Hypoxia, Oxygen, Reoxygenation, and Angiogenesis Xingjiang Yu, Jennifer S. Yu, and Eli Bar 7. Linear Energy Transfer and Relative Biological Effectiveness Yvonne Pham and Chirag Shah 8. Assays for Cell, Tissue, and Solid Tumors C. Marc Leyrer, Ehsan H. Balagamwala, and Camille Berriochoa 9. Molecular Techniques, Assay Systems, and Signaling in Radiobiology Kailin Yang and Jennifer S. Yu 10. Biology of Cancer Kailin Yang and Jennifer S. Yu 11. Model Tumor Systems and Predictive Assays C. Marc Leyrer, Camille Berriochoa, and Ehsan H. Balagamwala 12. Cell Kinetics Matthew C. Ward and Richard Blake Ross 13. Factors Influencing Tumor Control and Complications Daesung Lee 14. Impact of Time, Dose, and Fractionation in Radiation Oncology Daesung Lee 15. Effects of Total Body Irradiation Sudha Amarnath 16. Radiation Sensitizers, Radioprotectors, and Bioreductive Drugs Aditya Juloori and Michael A. Weller 17. Radiation Carcinogenesis Bindu V. Manyam and Michael A. Weller 18. Effects of Radiation on Hereditary Damage, Mutations, and Chromosome Aberrations Camille Berriochoa, C. Marc Leyrer, and Anthony Mastroianni 19. Effects of Radiation on the Embryo and Fetus Yvonne Pham and Steven Oh 20. Doses and Risks in Nonradiation Oncology Subspecialties Frank Dong, Kevin Wunderle, and Salim Balik 21. Radiation Protection Taoran Cui and Peng Qi 22. Alternative Radiation Therapy Modalities Susan Kost and Andrew Godley 23. Brachytherapy and Stereotactic Radiosurgery Sudha Amarnath 24. Gene Therapy HyeonJoo Cheon 25. Chemotherapy and Targeted Agents Nikhil Joshi and Neil Woody 26. Hyperthermia Sharvari Dharmaiah, Vinay Rao, and Jennifer S. Yu 27. Stem Cells Haidong Huang and Jennifer S. Yu 28. Immunotherapy Nikhil Joshi and Neil Woody 29. Radiogenomics Mohamed E. Abazeed Index
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