This book presents methods for the randomized allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. The authors compare various designs of clinical trials, include real examples of clinical trials, and present simulations of many procedures for small to moderate-sized samples. They also use results from the optimum design of experiments to create powerful and flexible adaptive designs.
This book presents methods for the randomized allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. The authors compare various designs of clinical trials, include real examples of clinical trials, and present simulations of many procedures for small to moderate-sized samples. They also use results from the optimum design of experiments to create powerful and flexible adaptive designs.
Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science. Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.
Inhaltsangabe
Introduction: Stories and Data. Adaptive Design: Controversies and Progress. Randomised Balanced Sequential Treatment Allocation. Response-Adaptive Designs for Binary Responses. Response-Adaptive Designs for Continuous Responses. Response-Adaptive Designs for Longitudinal Responses. Optimum Biased-Coin Designs with Covariates. Optimum Response-Adaptive Designs with Covariates. Optimal Response-Adaptive Designs with Constraints. Adaptive Design: Further Important Issues. Appendix. Bibliography. Index.
