Sin-Ho Jung

Randomized Phase II Cancer Clinical Trials

• Gebundenes Buch

Produktbeschreibung

Suitable for cancer clinicians and biostatisticians, this book explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 244
• Erscheinungstermin: 2. Mai 2013
• Englisch
• Abmessung: 257mm x 183mm x 20mm
• Gewicht: 640g
• ISBN-13: 9781439871850
• ISBN-10: 143987185X
• Artikelnr.: 36759944

Autorenporträt

Sin-Ho Jung is a professor of biostatistics and bioinformatics at Duke University School of Medicine. He earned a PhD from the University of Wisconsin-Madison. His research interests include clinical trial design, survival analysis, longitudinal data analysis, clustered data analysis, ROC curve analysis, and microarray studies.

Inhaltsangabe

Introduction. Single-Arm Phase II Trial Designs. Inference on the Binomial
Probability in Single-Arm Multistage Clinical Trials. Single-Arm Phase II
Clinical Trials with Time-to-Event Endpoints. Single-Arm Phase II Trials
with Heterogeneous Patient Populations: Binary and Survival Outcomes.
Randomized Phase II Trials for Selection: No Prospective Control Arms.
Randomized Phase II Cancer Clinical Trials with a Prospective Control on
Binary Endpoints (I): Two-Sample Binomial Test. Randomized Phase II Cancer
Clinical Trials with a Prospective Control on Binary Endpoints (II):
Fisher's Exact Test. Randomized Phase II Trials with Heterogeneous Patient
Populations: Stratified Fisher's Exact Test. Randomized Phase II Clinical
Trials Based on Survival Endpoints: Two-Sample Log-Rank Test. Some Flexible
Phase II Clinical Trial Designs. Index.