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This manual contains information on how new drugs are developed and the challenges related to it; sessions on principles and process of prescription and dispensing to improve the skill and attitude of good prescribing and dispensing practices of professionals; chapters to indicate good transportation requirements of veterinary drugs, dispensing environment, stock management and quality assurance of drugs at stock so as to maintain the drug quality; information on the consequences of irrational drug utilization and drug resistance as future threat; and the importance, sources, handling and transportation of vaccines, and use of updated veterinary drugs information. The document also contains different drug chemistry formulas and arithmetic calculations which could help prescribers and dispensers on their day to day practices to ensure the rational use of veterinary drugs and vaccines. It will help animal health and veterinary drug professionals to use veterinary drugs and vaccinesrationally and enhance the quality of veterinary pharmaceutical services so as to decrease the economic losses and public health hazards due to diseases of livestock.