This book presents a theoretically and empirically informed analysis of technology transfer of a computer-based HIS within a South-North-South network involving Mozambique, South Africa and Norway. Technology transfer from the North to the South has historically been problematic, including the domain of ICTs more broadly and Health Information Systems in particular. It is argued that the diffusion perspective, the dominant approach employed to technology transfer, is inherently problematic, and there is the urgent need to identify alternative conceptualizations. Against this backdrop, this book addresses two research aims: (i) to develop a theoretical conceptualization of technology transfer based on a translation perspective ; and, (ii) to understand and address the (empirical) challenges shaping the translation process of a computer-based Health Information Systems in South-North-South networks.