Reactive Oxygen Species - Double Faced Companions - Totan, Alexandra
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All the deviations from redox homeostasis are cumulatively often named as ¿oxidative stress¿. Prolonged, excessive and inadequate response to a given challenge (condition comprehensively defined as stress), leads to a stable alteration of homeostasis perceived as disease. In normal cells reactive oxygen species are generated in a highly controlled manner as they are very important actors involved in vital cell processes (cell division, autophagy, inflammation, immune regulation and stress-related responses) regulation. At low concentration, the reactive oxygen species promote cell survival and…mehr

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Produktbeschreibung
All the deviations from redox homeostasis are cumulatively often named as ¿oxidative stress¿. Prolonged, excessive and inadequate response to a given challenge (condition comprehensively defined as stress), leads to a stable alteration of homeostasis perceived as disease. In normal cells reactive oxygen species are generated in a highly controlled manner as they are very important actors involved in vital cell processes (cell division, autophagy, inflammation, immune regulation and stress-related responses) regulation. At low concentration, the reactive oxygen species promote cell survival and proliferation, whereas at intermediate concentration they lead to a transient or permanent cell cycle arrest and induces cell differentiation. However, uncontrolled generation of these oxidants can lead to oxidative stress and cytotoxicity, causing disruption and loss of important cellular functions and development of complex heterogeneous diseases.
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Autorenporträt
Alexandra Totan is currently the Associate Professor in the Biochemistry Department, ¿Carol Davilä University of Medicine and Pharmacy. Her research focuses on various areas of interest, such as saliva as a diagnosis and monitoring fluid for oral and systemic diseases, oxidative stress, the effects of PLGA nanoparticles and AKT signalling pathways