Reactive Oxygen Species (ROS) Based Therapeutics - Allimuthu, Dharmaraja
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ROS a "double edged sword": Evading persistent drug resistance in cancer and bacteria is quintessential to restore health in humans, and impels intervention strategies. A distinct property of the cancer phenotype is enhanced glucose metabolism and oxidative stress. Reactive oxygen species (ROS) are metabolic byproducts of aerobic respiration and are responsible for maintaining redox homeostasis in cells. Redox balance and oxidative stress are orchestrated by antioxidant enzymes, reduced thiols and NADP(H) cofactors, which is critical for cancer cells survival and progression. Similarly,…mehr

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Produktbeschreibung
ROS a "double edged sword": Evading persistent drug resistance in cancer and bacteria is quintessential to restore health in humans, and impels intervention strategies. A distinct property of the cancer phenotype is enhanced glucose metabolism and oxidative stress. Reactive oxygen species (ROS) are metabolic byproducts of aerobic respiration and are responsible for maintaining redox homeostasis in cells. Redox balance and oxidative stress are orchestrated by antioxidant enzymes, reduced thiols and NADP(H) cofactors, which is critical for cancer cells survival and progression. Similarly, Escherichia coli (E. coli) and life-threatening infectious pathogens such as Staphylococcus aureus (SA) and Mycobacterium tuberculosis (Mtb) are appreciably sensitive to changes in the intracellular oxidative environment. Thus, small molecules that modulate antioxidant levels and/or enhance intracellular ROS could disturb the cellular oxidative environment and induce cell death, and hence could serve as novel therapeutics. Presented here are a collection of approaches that involve ROS modulation in cells as a strategy to target cancer and bacteria.
Autorenporträt
Dharmaraja Allimuthu a obtenu sa licence en chimie au Government Arts College-Salem en 2003 et sa maîtrise en 2005 à l'université Bharathidasan de Trichy, dans l'État du Tamil Nadu, en Inde. Dharmaraja a obtenu son doctorat à l'Indian Institute of Science Education and Research de Pune, en Inde. Il est actuellement chercheur postdoctoral à la Case Western Reserve University, dans l'Ohio, aux États-Unis.