Anna Letizia Allegra Mascaro

Reactive structural plasticity of climbing fibres after laser axotomy

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex

• Broschiertes Buch

Produktbeschreibung

The regenerative properties of neurons in the adult brain are generally very poor. Nonetheless, few populations of neurons, like the object of this study, retains regrowth capacities in adult being. This book is focused on the regenerative properties of adult cerebellar neurons. This study exploit high energy pulsed lasers to dissect single neuronal branches. In vivo two-photon imaging allows monitoring the remodeling of the dissected neuron on the long term with subcellular resolution. We found that climbing fibers (a type of cerebellar axons) are capable of regrowing after laser dissection of single axonal branches and that the regrowth of new branches from the injured neurons requires the expression of a growth associated protein, GAP-43. Axonal degeneration and modifications in GAP-43 expression profiles are associated with a plethora of neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, diabetic neuropathy, schizophrenia and Alzheimer s and Parkinson s diseases. In this respect, these results may be helpful in assessing and validating new therapeutic strategies to prevent degeneration and promote axonal regrowth.

Produktdetails

• Verlag: Scholar's Press
• Seitenzahl: 116
• Erscheinungstermin: 13. September 2014
• Englisch
• Abmessung: 220mm x 150mm x 8mm
• Gewicht: 191g
• ISBN-13: 9783639700343
• ISBN-10: 3639700341
• Artikelnr.: 41469256

Autorenporträt

I graduated in Chemistry of Biological Molecules 110/110 cum laude in 2007, then in 2010 I got the PhD on Biophysics at the University of Florence, Italy. My main research interest is neuronal plasticity, both structural and functional, and in detail how it can trigger the recovery of injured brain areas.