Recent Advancement in Prodrugs

Herausgeber: Chauhan, Durgesh Nandini; Singh Chauhan, Nagendra; Shah, Kamal

• Gebundenes Buch

Produktbeschreibung

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 350
• Erscheinungstermin: 28. Mai 2020
• Englisch
• Abmessung: 260mm x 183mm x 23mm
• Gewicht: 856g
• ISBN-13: 9780367348366
• ISBN-10: 0367348365
• Artikelnr.: 69935642

Autorenporträt

Kamal Shah, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pradeep Mishra

Inhaltsangabe

Recent advancements in New drug design and development of prodrugs.
Codrugs: Optimum use through prodrugs. Role of Prodrugs in Drug Design.
Prodrugs for enhancement of lipophilicity. Lipidic Prodrugs for Drug
Delivery: Opportunities and Challenges. The progress of prodrugs in drug
solubility. Prodrugs for CNS drug delivery. Prodrugs for Cancer Treatment.
Prodrugs in cancer nanomedicine and therapy. Nitroreductases in prodrug
therapies. Prodrug approach using carboxylesterase: Different substrate
specificities of human carboxylesterase isozymes. Mathematical models for
ADME of prodrugs. Prodrug Approaches for Natural Products. Biotechnology
based prodrug approach for cell-specific targeting: its theoretical basis
and application.