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Dihydropyrimidinone is one of the significant scaffold in synthetic organic chemistry which shows various biological aspects. Various methods have been reported for the synthesis of dihydropyrimidinone derivatives via muiti component reactions by using various bronsted and Lewis acid catalysts, various homogeneous and heterogeneous catalyst. We expectation that this content will inspire for the researchers to develop creative synthetic routes which might be commercialise the molecules essential in the field of drug discovery.